上海佰世凯化学科技有限公司

4008190228-0125
 现货 NVP-BEZ235(Free Base) P13K and mTOR 抑制剂
  • 现货 NVP-BEZ235(Free Base) P13K and mTOR 抑制剂
  • 现货 NVP-BEZ235(Free Base) P13K and mTOR 抑制剂

    参考价格: ¥0.00
    品  牌:chembest
    产品型号:C13946 (98%)
    适用范围:高教
    所在地区:上海
    上架时间:2018年07月30日
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    详细说明

    NVP-BEZ235(Free Base)
    Molecula Formula:C30H23N5O
    Molecular Weight: 469.54
    Appearance: White solid
    Purity:98%
    CAS[915019-65-7]

    Biological Activity:
    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells.

    References:
    1.Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Molecular Cancer Therapeutics (2008), 7(7), 1851-1863.
    2.NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations. Cancer Research (2008), 68(19), 8022-8030.

    (产品仅适用于科学实验,不得用于其他目的).