上海佰世凯化学科技有限公司

4008190228-0125
 现货 Paclitaxel/紫杉醇
  • 现货 Paclitaxel/紫杉醇
  • 现货 Paclitaxel/紫杉醇

    参考价格: ¥0.00
    品  牌:chembest
    产品型号:C11697 (99%)
    适用范围:高教
    所在地区:上海
    上架时间:2018年07月30日
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    Paclitaxel/紫杉醇
    Molecula Formula:C47H51NO14
    Molecular Weight: 853.92
    Appearance: White solid
    Purity:99%
    CAS[33069-62-4]

    Biological Activity:
    Paclitaxel (Taxol) is a microtubule polymer stabilizer with an IC50 of 0.1 pM for human endothelial cells. It selectively inhibits the proliferation of human endothelial cells (ECs) at ultra low concentrations (0.1-100 pM), while it inhibits non-endothelial type human cells at 10(4) - to 10(5) -fold higher concentrations, with IC50 = 1-10 nM. The selectivity of paclitaxel inhibition of cell proliferation is also species specific, as mouse ECs are not sensitive to paclitaxel at ultra low concentrations. They are inhibited by higher concentrations of paclitaxel with IC50 = 1-10 nM. Inhibition of human ECs by paclitaxel at ultra low concentrations does not affect the cellular microtubule structure. Paclitaxel blocks cells in G2-M, and this may result in a schedule-dependent effect on paclitaxel cytotoxicity.


    (产品仅适用于科学实验,不得用于其他目的).