上海佰世凯化学科技有限公司

第7年
 现货 MK-2206   Akt1, Akt2, Akt3抑制剂
  • 现货 MK-2206   Akt1, Akt2, Akt3抑制剂
  • 现货 MK-2206 Akt1, Akt2, Akt3抑制剂

    参考价格: ¥0.00
    品  牌:chembest
    产品型号:C13900 (99%)
    适用范围:高教
    所在地区:上海
    上架时间:2017年04月26日
    留言咨询
    与企业取得联系时请告知该信息获取自中国教育装备采购网
    我要分享
    详细说明

    MK-2206
    Molecula Formula:C25H21N5O.2(HCl)
    Molecular Weight: 480.39
    Appearance: White solid
    Purity:99%
    CAS[1032350-13-2]

    Biological Activity:
    MK-2206 is an allosteric inhibitor and is activated by the pleckstrin homology domain. MK-2206 inhibits auto-phosphorylation of both Akt T308 and S473. MK-2206 also prevents Akt-mediated phosphorylation of downstream signaling molecules, including TSC2, PRAS40 and ribosomal S6 proteins. MK-2206 inhibits Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292) more potently when compared to Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6). MK-2206 also shows synergistic responses in combination with cytotoxic agents such as erlotinib or lapatinib in lung NCI-H460 or ovarian A2780 tumor cells. MK-2206 or siRNA-mediated Akt inhibition strongly activates autophagy in human glioma cells. While eukaryotic elongation factor-2 (eEF-2) silencing could suppress MK-2206-induced-autophagy, with a promotion of apoptotic cell death.

    References:
    [1]Yan L, AACR Annual Meeting 2009: Abstract Number: DDT01-1.

    [2] Hirai H, et al. Mol Cancer Therapy, 2010, 9(7), 1956-1967.

    [3] Cheng Y, et al, Cancer Res, 2011, 71(7), 2654-2663.

    产品仅适用于科学实验,不得用于其他目的.