Product Name: RN 1 dihydrochloride(RN-1 HCL)
Synonyms: LSD1 Inhibitor IV, RN-1,HCl;BHC110 Inhibitor IV;KDM1 Inhibitor IV;MOA Inhibitor III
Chemical Name: 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Storage:Store at -20°C
Solubility:Soluble to 20 mM in water and to 20 mM in DMSO with gentle warming
Appearance: Yellow solid
Purity: >98% by HPLC
Potent lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC50 values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.