Synonyms: Ro 40-5967;Posicor
Chemical Name: (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester 2-methoxy-acetic acid, dihydrochloride
Mibefradil is a general calcium channel blocker that shows modest
selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 μM,
respectively).It is a potent vasodilator, increasing coronary artery flow with
an EC50 value of 54 nM.Mibefradil has minimal negative inotropic effects,
supporting its use as an anti-hypertensive agent.