Product Name: Plerixafor(AMD3100)
Chemical Name: 1,1-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
CAS No. : 110078-46-1
Molecular Formula: C28H54N8
Molecular Weight: 502.78
Usage: Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin?s lymphoma (NHL) and multiple myeloma (MM).