Product Name: Sofosbuvir(PSI-7977)
Synonym: PSI 7977;Sofosbuvir;GS-7977;PSI7977
Chemical Name: N-[[P(S),2R]-2-Deoxy-2-fluoro-2-methyl-P-phenyl-5-uridylyl]-L-alanine 1-methylethyl ester;Isopropyl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate
CAS No. : 1190307-88-0
Molecular Formula: C22H29FN3O9P
Molecular Weight: 529.45
Usage: PSI-7977 is an investigational nucleotide analog currently in Phase 2 for treatment of chronic HCV infection. PSI-7851 is a mixture of two similar molecules, PSI-7976 and PSI-7977, which exist in PSI-7851 as isomers of each other. Once inside a liver cell, both molecules are rapidly converted to the same active triphosphate. Given the ability to more easily manufacture PSI-7977, and potentially advantageous in vitro characteristics, PSI-7977 was selected for further clinical development. Antiviral agents.