上海佰世凯化学科技有限公司

4008190228-0125
 Brefeldin A	/布雷菲德菌素A	CAS:20350-15-6
  • Brefeldin A	/布雷菲德菌素A	CAS:20350-15-6
  • Brefeldin A /布雷菲德菌素A CAS:20350-15-6

    参考价格: ¥380.00
    品  牌:Chembest
    产品型号:C13399
    适用范围:高教
    所在地区:上海
    上架时间:2018年07月30日
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    RMB:380.00/5mg

    Product Name: Brefeldin A(BFA)
    Synonym: (+)-Brefeldin A; Ascotoxin; Brefeldin; Cyanaein; Cyanein; Decumbin; Nectrolide; Synergisidin
    Chemical Name: 1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one;(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-4H-Cyclopent[f]oxacyclotridecin-4-one
    CAS No. : 20350-15-6
    Molecular Formula: C16H24O4
    Molecular Weight: 280.36
    Appearance: White solid
    Solubility: Soluble in ethanol (5 mg/mL) and DMSO (20 mg/mL) Soluble in methanol. Does not mix with water
    Purity: >99%
    Usage: Brefeldin A (BFA) is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. The compound induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus. Studies show that it blocks the GTP-dependent interaction of ARF with the Golgi membrane, thus inhibiting the assembly of coatomer onto the membrane. Research shows that BFA can induce apoptosis in Neuroendocrine tumor cells by activating caspase-3, and inhibits cell growth by targeting the cell cycle in prostate cancer cells.