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Brefeldin A	/布雷菲德菌素A	CAS:20350-15-6

Brefeldin A /布雷菲德菌素A CAS:20350-15-6

参考价格:¥380.00
品  牌:Chembest
产品型号:C13399
适用范围:高教
所在地区:华东 上海
上架时间:2017-07-24
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RMB:380.00/5mg

Product Name: Brefeldin A(BFA)
Synonym: (+)-Brefeldin A; Ascotoxin; Brefeldin; Cyanaein; Cyanein; Decumbin; Nectrolide; Synergisidin
Chemical Name: 1,6,7,8,9,11aβ,12,13,14,14αa-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent(f)oxacyclotridecin-4-one;(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-4H-Cyclopent[f]oxacyclotridecin-4-one
CAS No. : 20350-15-6
Molecular Formula: C16H24O4
Molecular Weight: 280.36
Appearance: White solid
Solubility: Soluble in ethanol (5 mg/mL) and DMSO (20 mg/mL) Soluble in methanol. Does not mix with water
Purity: >99%
Usage: Brefeldin A (BFA) is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. The compound induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus. Studies show that it blocks the GTP-dependent interaction of ARF with the Golgi membrane, thus inhibiting the assembly of coatomer onto the membrane. Research shows that BFA can induce apoptosis in Neuroendocrine tumor cells by activating caspase-3, and inhibits cell growth by targeting the cell cycle in prostate cancer cells.