上海佰世凯化学科技有限公司

4008190228-0125
 Triptolide(TPL)/雷公藤甲素 CAS:38748-32-2
  • Triptolide(TPL)/雷公藤甲素 CAS:38748-32-2
  • Triptolide(TPL)/雷公藤甲素 CAS:38748-32-2

    参考价格: ¥0.00
    品  牌:chembest
    产品型号:C12310
    适用范围:高教
    所在地区:上海
    上架时间:2018年07月30日
    留言咨询
    4008190228-0125
    与企业取得联系时请告知该信息获取自中国教育装备采购网
    我要分享
    详细说明
    雷公藤甲素; 雷公藤内酯醇; 雷公藤多甙
    Product Name:Triptolide(TPL)
    CAS No.:38748-32-2
    Synonyms:PG490 ; PG 490 ; PG-490
    Chemical Name:(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
    Purity:>98%
    Molecular Formula:C20H24O6
    Molecular Weight:360.41
    Biological Activity:
    Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.
    IC50 Value:
    Target: NF-kB; Apoptosis inducer
    in vitro: Triptolide is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties.
    Triptolide is shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. Triptolide inhibits the proliferation and colony formation of tumor cells at extremely
    low concentrations (2-10 ng/mL). Triptolide has an inhibitory activity on breast, stomach and leukemia cell line HL-60 cells.
    Triptolide induces apoptosis in tumor cells by blocking NF-κB activation and sensitizing tumor cells for TNF-&alpha induced
    programmed cell death.
    in vivo: bTriptolide synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus
    host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor
    necrosis factor (TNF-α) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction. Triptolide treatment for 2-3 weeks inhibits the growth of xenografts formed by four different tumor cell lines (B16 melanoma, MDA-435 breast cancer,
    TSU bladder cancer, and MGC80-3 gastric carcinoma), indicating that TPL has a broad spectrum of activity against tumors that contain both wild-type and mutant forms of p53. In addition, Triptolide inhibits experimental metastasis of B16F10 cells to the lungs and spleens
    of mice. Triptolide has in vitro and in vivo activities against mouse models of polycystic kidney disease. LD50: Mice 0.83mg (i.v.).
    雷公藤系列相关产品:
    货号 CASNo. 英文名 中文名
    C10381 34157-83-0 Celastrol(Tripterin);tripterine;(2R,4aS,6aS,6aR,14aS,14bR)-10-Hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylicacid;(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacid;3-Hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacid;3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oicAcid;NSC70931;10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylicacid 雷公藤红素;南蛇藤素;南蛇藤醇
    C11845 1258-84-0 Pristimerin(NSC99281);(9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tertraen-29-oicacidmethylester;Celastrolmethylester;(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester;3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacid,methylester 扁塑藤素
    C12310 38748-32-2 Triptolide(TPL);PG490;PG490;PG-490;(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one 雷公藤甲素;雷公藤内酯醇;雷公藤多甙
    C17228 38647-10-8 Tripdiolide;Triptodiolide 雷公藤乙素;雷公藤羟内酯;雷公藤内酯二醇
    C16808 37239-51-3 Wilfordine;Wilfordin;(8R,9R,10R,11S,12S,13R,14R,15S,21S,22S,23R)-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-18,21-dihydroxy-8,18,21-trimethyl-,8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione;8,11-Epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione,10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-18,21-dihydroxy-8,18,21-trimethyl-,(8R,9R,10R,11S,12S,13R,14R,15S,21S,22S,23R)- 雷公藤定碱;雷公藤碱;雷公藤定
    C12391 37239-47-7 Wilforgine;Wilforgin;Evonimine,8-(acetyloxy)-O2-deacetyl-8-deoxo-O2-(3-furanylcarbonyl)-,(8α)-;3-Furancarboxylicacid,10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-21-hydroxy-8,18,21-trimethyl-5,17-dioxo-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridin-14-ylester,(8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-;(8alpha)-8-(Acetyloxy)-O2-deacetyl-8-deoxo-O2-(3-furanylcarbonyl)-evonimineWilforgin;3-Furancarboxylicacid(8R,9R,10R,11S,12R,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-21-hydroxy-8,18,21-trimethyl-5,17-dioxo-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridin-14-ylester;AIDS088959;AIDS-088959;BRN0078231;Evonimine,8-(acetyloxy)-O(sup2)-deacetyl-8-deoxo-O(sup2)-(3-furanylcarbonyl)-,(8-alpha)- 雷公藤吉碱;雷公藤晋碱;雷公藤精碱
    C12392 11088-09-8 Wilforine;26-Deoxywilfordine;Evonimine,8-(acetyloxy)-O2-benzoyl-O2-deacetyl-8-deoxo-,(8α)-;8,11-Epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione,10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-,(8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-;(8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione 雷公藤次碱
    C16807 37239-48-8 Wilfortrine;Wilfortrin;3-Furancarboxylicacid,(8R,9R,10R,11S,12R,13R,14R,15S,21S,22S,23R)-10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-18,21-dihydroxy-8,18,21-trimethyl-5,17-dioxo-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridin-14-ylester 雷公藤春碱
    C16809 345954-00-9 WilfornineA;8,11-Epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione,10,13,14,22,23-pentakis(acetyloxy)-12-[(acetyloxy)methyl]-18-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-,(8R,9R,10R,11S,12R,13R,14R,15S,21S,22S,23R)- 雷公藤宁碱A
    C16754 168009-85-6 TriptonineB;TriptonineB(Tripterygiumwilfordii);(-)-TriptonineB;18-O-(3-Furoyl)wilfortrine;Wilfortrine26-(3-furoate);3-Furancarboxylicacid,10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-7,8,9,10,12,13,14,15,17,18,19,20-dodecahydro-21-hydroxy-8,18,21-trimethyl-5,17-dioxo-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H[1,9]dioxacyclooctadecino[4,3-b]pyridine-14,18-diylester,(8R,9R,10R,11S,12R,13R,14R,15S,18R,21S,22S,23R)- 18-O-(3-糠酰)雷公藤春碱
    C12393 84104-71-2 WilforlideA 雷公藤内酯甲;雷公藤酯甲
    C12311 38647-11-9 Triptonide;(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-Isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione;NSC165677;PG492 雷公藤内酯酮;雷藤酮
    C10649 107316-88-1 Demethylzeylasteral;(9beta,13alpha,14beta,20alpha)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oicacid 去甲泽拉木醛
    C12312 74285-86-2 Triptophenolide;(+)-Triptophenolide;Hypolide;(3bR,9bS)-3b,4,5,9b,10,11-Hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)phenanthro[1,2-c]furan-1(3H)-one 雷酚内酯;山海棠素

    Triptolide(TPL)/雷公藤甲素 CAS:38748-32-2