规格: 100 UG
名称: Claudin-18 - ABfinity™ Recombinant Rabbit Monoclonal Antibody
ABfinity™ Recombinant Rabbit Monoclonal Antibody validated to Mouse, Human and expected reactivity with human, chimpanzee, Rhesus monkey, equine, mouse, and rat. This antibody is validated for use in Western Blot and Immunohistochemistry. Claudin-18 is encoded by the 51208 gene, also known as SFTA5, SFTPJ, CLDN18, Claudin 18.
Claudin-18 is a tight junction protein expressed as lung- and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene (1). The lung-specific form is a downstream target gene regulated by the T⁄EBP⁄NKX2.1 transcription factor (1). A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human (1). Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein (1). Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in View Morethe cell-cell borders of these cells (1). These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach (1). Claudin-18 expression has also been reported in the inner ear (2). Because of its highly restricted expression pattern in normal tissues and frequent activation in numerous human cancers, claudin-18 may represent an important target for antibody therapy (3).
Niimi T, et al. (2001) Claudin-18, a novel downstream target gene for the T⁄EBP⁄NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol 21:7380-7390.
Kitajiri SI, et al. (2004) Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. Hear. Res. 187:25-34.
Sahin, U. et al. (2008) Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. Clin. Cancer Res. 14:7624-34.
For Research Use Only. Not for any animal or human therapeutic or diagnostic use.