名称: PROTEOLIPID PROTEIN (PLP), CHKX-500UL
Species Reactivity Note: Other species have not yet been tested. It is expected that the antibody will also react with human due to immunogen sequence similarity.
Application Notes: Immunohistochemistry: 1:100-1:200 using 2% paraformaldehyde fixed tissue.
Immunocytochemistry: 1:100-1:200 using 2% paraformaldehyde fixed cells.
Optimal working dilutions must be determined by end user.
Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Entrez Gene Summary: This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene.