产品名称：anti-mouse/human/rat EGFR Purified Polyclonal
Also known as: EGFR, epidermal growth factor
Reactivity Human, Mouse, Rat
Reported Applications Immunohistochemical Staining, Immunoprecipitation, Western Blotting
Description: The EGFR polyclonal antibody reacts with mouse, human, and rat EGFR. The antibody was raised against the peptide edmddvvdadey, which represents amino acids 1005-1016 and is located near the carboxy terminus of human EGFR. The EFGR family is a group of four structurally similar tyrosine kinases (EGFR, HER2/neu, ErbB-3, and ErbB-4) that dimerize on binding with a number of ligands, including EGF and transforming growth factor alpha (1&2). The 170 kDa epidermal growth factor receptor binds EGF which activates a tyrosine-specific protein kinase activity intrinsic to the receptor (3&4). Epidermal growth factor receptor overexpression is pronounced in virtually all squamous carcinomas and is also found in > or = 65% of large cell and adenocarcinomas. It is not expressed in situ by small cell lung carcinoma. Overexpression of EGFR is one of the earliest and most consistent abnormalities in bronchial epithelium of high-risk smokers (1).
eBioscience 14-6747-63 anti-mouse/human/rat EGFR Purified Polyclonal 10 ug 708
eBioscience 14-6747-81 anti-mouse/human/rat EGFR Purified Polyclonal 50 ug 1668