产品名称：PHAP I (CT), pAb
Long Term Storage: +4°C
Immunogen: Synthetic peptide corresponding to the sequence near the C-terminus of human PHAP I.
Application: Immunohistochemistry (2µg/ml)
Western Blot (0.5-2.0µg/ml)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human, mouse and rat PHAP I. Detects a band of ~32kDa by Western blot.
Purity Detail: Peptide affinity purified.
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Miscellaneous/General: The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were identified as important regulators of mitochondrial mediated apoptosis. PHAP appears to facilitate apoptosome mediated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both ras- and myc mediated cell transformation.