Alternative Name: Prostaglandin J2
Long Term Storage: -20°C
Immunogen: 15-deoxy-D12,14-Prostaglandin J2.
Optimal conditions must be determined individually for each application.
Specificity: Species independent.
Purity Detail: Sodium sulfate precipitation purified.
Formulation: Liquid. In PBS containing 1.0mg/ml Rabbit IgG and 0.1% sodium azide.
Miscellaneous/General: 15-deoxy-Delta12,14-Prostaglandin J2 (15-d-PGJ2) is one of the ultimate dehydration products of PGD2, formed via the intermediate Delta12-PGJ2. 15-d-PGJ2 is physiologically present in body fluids at concentration of 10-12 to 10-9 M, but increases dramatically under stress such as infection and inflammation. 15-d-PGJ2 exerts both pro- and anti-inflammatory effects in a cell-type and concentration-dependent manner, with many of these effects mediated via binding to the gamma isoform of the peroxisome proliferators-activated receptor (PPAR-gamma). 15-d-PGJ2 appears to induce HO-1 expression by a PPAR-gamma-independent mechanism mediated by the generation of reactive oxygen species (ROS).