产品名称：Death receptor 4, pAb
Alternative Name: DR, TRAIL
Long Term Storage: +4°C
Immunogen: Synthetic peptide corresponding to a portion of human DR4 mature protein.
Application: Western Blot (0.5µg/ml, ECL)
Optimal conditions must be determined individually for each application.
Specificity: Recognizes human Death Receptor 4.
Purity Detail: DEAE purified.
Formulation: Liquid. In PBS containing 0.02% sodium azide.
Miscellaneous/General: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas Ligand (CD95L/Apo-1L) of the TNF superfamily, through their death domain containing receptors, TNF-R1 and Fas (CD95/Apo-1). A member of the TNF receptor family was identified and alternately designated DR4 (death receptor 4) and TRAIL-R1. The ligand for this death receptor has been identified and termed TRAIL. DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes (PBLs), small intestine and thymus. Like TNF-R1, Fas and DR3, DR4 mediates apoptosis and NFkappaB activation in many tissues and cells.