CAS number: 82410-32-0
Molecular weight: 255.2
Ganciclovir (GCV) is a guanosine analog used as a prodrug to obtain a suicide effect in cells transfected with the herpes virus thymidine kinase gene (HSV-tk).
HSVTK phosphorylates GCV to GCV-monophosphate which is further converted to GCV-diphosphate and GCV-triphosphate by host kinases. GCV-triphosphate causes premature DNA chain termination and apoptosis. Ganciclovir is approved by the FDA for the treatment of cytomegalovirus (CMV) infections.