Specificity: TLR2 agonist
Working concentration: 106-108 cells/ml
Endotoxin level: >1 EU/109 cells
Solubility: Insoluble (resuspended HKSA results in a cloudy suspension)
HKSA is shipped at room temperature and should be stored at 4°C. Upon resuspension, prepare aliquots of HKSA and store at 4°C for short term storage or -20°C for long storage. Product is stable 1 month at 4°C and 6 months at -20°C when properly stored.
HKSA is a lyophilized heat-killed preparation of Staphyloccocus aureus, a Gram-positive extra-cellular growing bacterium. HKSA is recognized mainly by TLR2. HKSA induces tolerance to a secondary HKSA stimulation but causes priming to LPS, suggesting a differential regulation of cytokines and chemokines in gram-positive- and gram-negative-induced inflammatory events.
invivogen tlrl-hksa HKSA 10e10 cells 1512
invivogen tlrl-hksc HKSC 10e9 cells 1232
invivogen tlrl-hksp HKSP 10e10 cells 1372