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CAS No. : 138168-48-6
MCE 国际站：Tyroserleutide
产品活性：Tyroserleutide (YSL)，可从猪脾脏的降解产物中分离得到，是一种小分子三肽，在体内外均可抑制肿瘤生长。
研究领域：Others
作用靶点：Others
In Vitro: Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells.
Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression.
Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells.
Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration.
In Vivo: Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice.
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