26S proteasome inhibitor
MG-132 is a peptide aldehyde (Z-Leu-Leu-Leu-al) that selectively blocks the proteolytic activity of the 26S proteasome.
This potent inhibitor is used as a tool for disrupting the proteasome-regulated degradation of intracellular proteins, such as IκB. Inhibition of IκB proteasomal degradation by MG-132 leads to the suppression of NF-κB activation [1].
Recent studies suggest that inhibition of the proteasome by MG-132 can induce autophagy by stabilizing Atg protein levels.
Specifications
Working concentration:0.2 - 20 μM.
CAS number: 133407-82-6.
Formula:C26H41N3O5.
Molecular weight: 475.62.
Solubility: 20 mg/ml in DMSO.
Contents
5 mg MG-132 provided lyophilized
MG-132 is shipped at room temperature.
Store lyophilized product at -20°C.
Lyophilized product is stable for 1 year when properly stored.