LL-37: Antimicrobial peptide
TLR2 and TLR4 inhibition by LL-37
LL-37, also known as hCAP18, is a synthetic peptide derived from the C-terminal region of the human cationic antimicrobial protein (hCAP). LL-37 exhibits a variety of immunomodulatory functions [1, 2]. Of note, it suppresses the inflammatory response induced by the activation of TLR2 and TLR4, which recognize different bacterial cell wall components [3].
