以下是Hansatech Clark型液相氧电极在线粒体功能和细胞生物能研究中的应用实例：
Mitochondrial Dysfunction线粒体功能障碍
Mitochondrial protein import clogging as a mechanism of disease
Liam P. Coyne, Xiaowen Wang, Jiyao Song, Ebbing de Jong, Karin Schneider, Paul T. Massa, Frank A. Middleton, Thomas Becker, Xin Jie Chen
bioRxiv 2022.09.20.508789;
https://doi.org/10.1101/2022.09.20.508789
N-acetyl-L-cysteine ameliorates mitochondrial dysfunction in ischemia/reperfusion injury via attenuating Drp-1 mediated mitochondrial autophagy
Mubashshir Ali, Heena Tabassum, M Mumtaz Alam, Suhel Parvez
Life Sciences, Volume 293, 2022, 120338, ISSN 0024-3205,
https://doi.org/10.1016/j.lfs.2022.120338
NAD supplementation improves mitochondrial performance of cardiolipin mutants
Jiajia Ji, Deena Damschroder, Denise Bessert, Pablo Lazcano, Robert Wessells, Christian A. Reynolds, Miriam L. Greenberg
Biochimica et Biophysica Acta (BBA) –Molecular and Cell Biology of Lipids, Volume 1867, Issue 4, 2022, 159094, ISSN 1388-1981,
https://doi.org/10.1016/j.bbalip.2021.159094
Effects of vitamin D (VD3) supplementation on the brain mitochondrial function of male rats, in the 6-OHDA-induced model of Parkinson’s disease
Ludmila Araújo de Lima, Pedro Lourenzo Oliveira Cunha, Iana Bantim Felicio Calou, Kelly Rose Tavares Neves, Heberty Tarso Facundo, Glauce Socorro de Barros Viana
Neurochemistry International, Volume 154, 2022, 105280, ISSN 0197-0186,
https://doi.org/10.1016/j.neuint.2022.105280
Mitochondria Bioenergetic Functions and Cell Metabolism Are Modulated by the Bergamot Polyphenolic Fraction
Algieri, C.; Bernardini, C.; Oppedisano, F.; La Mantia, D.; Trombetti, F.; Palma, E.; Forni, M.; Mollace, V.; Romeo, G.; Nesci, S.
Cells 2022, 11, 1401.
https://doi.org/10.3390/cells11091401
Neurology神经学
Myricitrin–a flavonoid isolated from the Indian olive tree (Elaeocarpus floribundus)–inhibits Monoamine oxidase in the brain and elevates striatal dopamine levels: therapeutic implications against Parkinson’s disease
Banerjee C, Nandy S, Chakraborty J, Kumar D.
Food & Function. 2022;13(12):6545-59.
https://doi.org/10.1039/D2FO00734G
Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point
Maha Tabet, Marya El-Kurdi, Muhammad Ali Haidar, Leila Nasrallah, Mohammad Amine Reslan, Deborah Shear, Jignesh D. Pandya, Ahmed F. El-Yazbi, Mirna Sabra, Stefania Mondello, Yehia Mechref, Abdullah Shaito, Kevin K. Wang, Riyad El-Khoury, Firas Kobeissy
Experimental Neurology, Volume 351, 2022, 113987, ISSN 0014-4886,
https://doi.org/10.1016/j.expneurol.2022.113987
Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer’s Disease
Bellanti Francesco, Bukke Vidyasagar Naik, Moola Archana, Villani Rosanna, Scuderi Caterina, Steardo Luca, Palombelli Gianmauro, Canese Rossella, Beggiato Sarah, Altamura Mario, Vendemiale Gianluigi, Serviddio Gaetano, Cassano Tommaso
Frontiers in Aging Neuroscience, 14, 2022, 1663-4365
https://doi.org/10.3389/fnagi.2022.890855
Pathogenic variants in GCSH encoding the moonlighting H-protein cause combined nonketotic hyperglycinemia and lipoate deficiency
Laura Arribas-Carreira, Cristina Dallabona, Michael A Swanson, Joseph Farris, Elsebet Østergaard, Konstantinos Tsiakas, Maja Hempel, Cecile Aquaviva-Bourdain, Stefanos Koutsoukos, Nicholas V Stence, Martina Magistrati, Elaine B Spector, Kathryn Kronquist, Mette Christensen, Helena G Karstensen, René G Feichtinger, Melanie T Achleitner, J Lawrence Merritt II, Belén Pérez, Magdalena Ugarte, Stephanie Grünewald, Anthony R Riela, Natalia Julve, Jean-Baptiste Arnoux, Kasturi Haldar, Claudia Donnini, René Santer, Allan M Lund, Johannes A Mayr, Pilar Rodriguez-Pombo, Johan L K Van Hove
Human Molecular Genetics, Volume 32, Issue 6, 15 March 2023, Pages 917–933,
https://doi.org/10.1093/hmg/ddac246
The Effect of Methylene Blue and Its Metabolite—Azure I—on Bioenergetic Parameters of Intact Mouse Brain Mitochondria
Gureev, A.P., Samoylova, N.A., Potanina, D.V. et al.
Moscow Suppl. Ser. B 16, 148–153 (2022).
https://doi.org/10.1134/S1990750822020044
Oncology肿瘤学
Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780)
Chiappetta G, Gamberi T, Faienza F, Limaj X, Rizza S, Messori L, Filomeni G, Modesti A, Vinh J.
Redox Biology. 2022 Jun 1;52:102294.
https://doi.org/10.1016/j.redox.2022.102294
Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice
Lim S, Deaver JW, Rosa-Caldwell ME, Haynie WS, Morena da Silva F, Cabrera AR, Schrems ER, Saling LW, Jansen LT, Dunlap KR, Wiggs MP.
Journal of Applied Physiology. 2022 Jan 1;132(1):58-72.
https://doi.org/10.1152/japplphysiol.00660.2021
PGC1α/βexpression predicts therapeutic response to oxidative phosphorylation inhibition in ovarian cancer
Ghilardi C, Moreira-Barbosa C, Brunelli L, Ostano P, Panini N, Lupi M, Anastasia A, Fiordaliso F, Salio M, Formenti L, Russo M.
Cancer Research. 2022 Apr 1;82(7):1423-34.
https://doi.org/10.1158/0008-5472.CAN-21-1223
Inhibition of LPAR6 overcomes sorafenib resistance by switching glycolysis into oxidative phosphorylation in hepatocellular carcinoma
Gnocchi D, Kurzyk A, Mintrone A, Lentini G, Sabbà C, Mazzocca A.
2022 Nov 1;202:180-9.
https://doi.org/10.1016/j.biochi.2022.07.016
Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress
Marx C, Sonnemann J, Maddocks OD, Marx-Blümel L, Beyer M, Hoelzer D, Thierbach R, Maletzki C, Linnebacher M, Heinzel T, Krämer OH.
Cancer & Metabolism. 2022 Jul 4;10(1):10.
https://doi.org/10.1186/s40170-022-00286-9
Pharmaceuticals制药
Propofol toxicity in the developing mouse heart mitochondria
Barajas MB, Brunner SD, Wang A, Griffiths KK, Levy RJ.
Pediatric research. 2022 Nov;92(5):1341-9.
https://doi.org/10.1038/s41390-022-01985-1
A Simplified Direct O2 Consumption-Based Assay to Test COX Inhibition
Perrone MG, Miciaccia M, Ferorelli S, Scilimati A.
Current Enzyme Inhibition. 2022 Mar 1;18(1):10-8.
http://dx.doi.org/10.2174/1573408018666220204104612
Aging衰老
Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan
Brandon J. Berry, Anežka Vodičková, Annika Müller-Eigner, Chen Meng, Christina Ludwig, Matt Kaeberlein, Shahaf Peleg, Andrew P. Wojtovich
bioRxiv 2022.05.11.491574;
https://doi.org/10.1101/2022.05.11.491574
ER reductive stress caused by Ero1αS-nitrosation accelerates senescence
Xinhua Qiao, Yingmin Zhang, Aojun Ye, Yini Zhang, Ting Xie, Zhenyu Lv, Chang Shi, Dongli Wu, Boyu Chu, Xun Wu, Weiqi Zhang, Ping Wang, Guang-Hui Liu, Chih-chen Wang, Lei Wang, Chang Chen
Free Radical Biology and Medicine, Volume 180, 2022, Pages 165-178, ISSN 0891-5849,
https://doi.org/10.1016/j.freeradbiomed.2022.01.006.
cep-1 mediated the mitohormesis effect of Shengmai formula in regulating Caenorhabditis elegans lifespan
Dejuan Zhi, Chengmu Zhao, Juan Dong, Wenjuan Ma, Shuaishuai Xu, Juan Yue, Dongsheng Wang
Biomedicine & Pharmacotherapy, Volume 152, 2022, 113246, ISSN 0753-3322,
https://doi.org/10.1016/j.biopha.2022.113246.
Antiaging Effect of 4-N-Furfurylcytosine in Yeast Model Manifests through Enhancement of Mitochondrial Activity and ROS Reduction
Pawelczak P, Fedoruk-Wyszomirska A, Wyszko E.
2022; 11(5):850.
https://doi.org/10.3390/antiox11050850
Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging
SenGupta T, Lefol Y, Lirussi L, Suaste V, Luders T, Gupta S, Aman Y, Sharma K, Fang EF, Nilsen H.
Aging (Albany NY). 2022 Nov 9; 14:8661-8687 .
https://doi.org/10.18632/aging.204375
Cardiology心脏病学
Metabolic alterations in a rat model of takotsubo syndrome
Nadine Godsman, Michael Kohlhaas, Alexander Nickel, Lesley Cheyne, Marco Mingarelli, Lutz Schweiger, Claire Hepburn, Chantal Munts, Andy Welch, Mirela Delibegovic, Marc Van Bilsen, Christoph Maack, Dana K Dawson
Cardiovascular Research, Volume 118, Issue 8, May 2022, Pages 1932–1946,
https://doi.org/10.1093/cvr/cvab081
Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease
Xu, Xinxiu, Jin, Kang, Bais, Abha S., Zhu, Wenjuan, Yagi, Hisato, Feinstein, Timothy N., Nguyen, Phong K., Criscione, Joseph D., Liu, Xiaoqin, Beutner, Gisela, Karunakaran, Kalyani B., Rao, Krithika S., He, Haoting, Adams, Phillip, Kuo, Catherine K., Kostka, Dennis, Pryhuber, Gloria S., Shiva, Sruti, Ganapathiraju, Madhavi K., Porter, George A., Jr., Lin, Jiuann-Huey Ivy, Aronow, Bruce, Lo, Cecilia W.
Cell Stem Cell, ISSN: 1934-5909, Vol: 29, Issue: 5, Page: 840-855.e7, May 2022
https://doi.org/10.1016/j.stem.2022.03.003
Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment
Balderas, E., Eberhardt, D.R., Lee, S. et al.
Nat Commun 13, 2769 (2022).
https://doi.org/10.1038/s41467-022-30236-4
Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy
Sayles, Nicole M., Southwell, Nneka, McAvoy, Kevin, Kim, Kihwan, Pesini, Alba, Anderson, Corey J., Quinzii, Catarina, Cloonan, Suzanne, Kawamata, Hibiki, Manfredi, Giovanni
Cell Reports, ISSN: 2211-1247, Vol: 38, Issue: 10, Page: 110475, 2022
https://doi.org/10.1016/j.celrep.2022.110475
Mitochondrial interactome quantitation reveals structural changes in metabolic machinery in the failing murine heart
Caudal, A., Tang, X., Chavez, J.D. et al.
Nat Cardiovasc Res 1, 855–866 (2022).
https://doi.org/10.1038/s44161-022-00127-4
Endocrinology内分泌学
SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway
Bai-Yu Li, Ying-Ying Guo, Gang Xiao, Liang Guo, Qi-Qun Tang, Molecular Metabolism
Volume 61, 2022, 101500, ISSN 2212-8778,
https://doi.org/10.1016/j.molmet.2022.101500.
CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis
Meng Ding, Yin-jun Ma, Ruo-qi Du, Wei-yu Zhou, Xin Dou, Qi-qi Yang, Yan Tang, Shu-wen Qian, Yun Liu, Dong-ning Pan, Qi-Qun Tang, Yang Liu.
Diabetes 1 September 2022; 71 (9): 1862–1879.
https://doi.org/10.2337/db21-0999
Hepatology肝病学
NRF2-mediated SIRT3 induction protects hepatocytes from ER stress-induced liver injury
Kim A, Koo JH, Lee JM, et al.
FASEB J. 2022; 36:e22170.
https://doi.org/10.1096/fj.202101470R
Infection感染学
Access to highly specialized growth substrates and production of epithelial immunomodulatory metabolites determine survival of Haemophilus influenzae in human airway epithelial cells
Hosmer J, Nasreen M, Dhouib R, Essilfie A-T, Schirra HJ, Henningham A, et al.
PLoS Pathog 18(1): e1010209. (2022)
https://doi.org/10.1371/journal.ppat.1010209
Naphthoquinone as a New Chemical Scaffold for Leishmanicidal Inhibitors of Leishmania GSK-3
Sebastián-Pérez, V.; Martínez de Iturrate, P.; Nácher-Vázquez, M.; Nóvoa, L.; Pérez, C.; Campillo, N.E.; Gil, C.; Rivas, L.
Biomedicines 2022, 10, 1136.
https://doi.org/10.3390/biomedicines10051136
The unusual convergence of steroid catabolic pathways in Mycobacterium abscessus
M. Crowe, J.M.C. Krekhno, K.L. Brown, J.A. Kulkarni, K.C. Yam, L.D. Eltis
Proc. Natl. Acad. Sci. U.S.A., 119 (40) e2207505119, (2022)
https://doi.org/10.1073/pnas.2207505119
Energy metabolism as a target for cyclobenzaprine: A drug candidate against Visceral Leishmaniasis
Marta Lopes Lima, Maria A. Abengózar, Eduardo Caio Torres-Santos, Samanta Etel Treiger Borborema, Joanna Godzien, Ángeles López-Gonzálvez, Coral Barbas, Luis Rivas, Andre Gustavo Tempone,
Bioorganic Chemistry, Volume 127, 2022, 106009, ISSN 0045-2068,
https://doi.org/10.1016/j.bioorg.2022.106009
FRB domain of human TOR protein induces compromised proliferation and mitochondrial dysfunction in Leishmaniadonovani promastigotes
Sudipta Chakraborty, Soumyajit Mukherjee, Priyam Biswas, Alok Ghosh, Anirban Siddhanta
Parasitology International, Volume 89, 2022, 102591, ISSN 1383-5769,
https://doi.org/10.1016/j.parint.2022.102591
Metabolomics代谢组学
Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation
Hall, A.R., Karwi, Q.G., Kumar, S. et al.
Sci Rep 12, 20551 (2022).
https://doi.org/10.1038/s41598-022-23847-w
Altered brown adipose tissue mitochondrial function in newborn fragile X syndrome mice
Yash R. Somnay, Aili Wang, Keren K. Griffiths, Richard J. Levy
Mitochondrion, Volume 65, 2022, Pages 1-10, ISSN 1567-7249,
https://doi.org/10.1016/j.mito.2022.04.003
